MUC4 Rare Tumor IHC Test | Lahalak Platform
Accurate test for diagnosing synovial sarcoma and pancreatic or lung cancers, providing specialized diagnostics that help design an effective treatment plan to combat these aggressive tumor types.
Scientific name: MUC4 Immunohistochemistry Test
Immunohistochemical assay for MUC4 (Mucin 4) aims to detect this membrane-associated mucoglycoprotein. MUC4 is a highly sensitive and specific marker for synovial sarcoma (SS), being expressed in >90% of cases regardless of histological type (monophagus, biphasic). It is also expressed in many adenocarcinomas, particularly of the pancreas and lung.
Service type
Laboratory test (Tissue)
Duration
10-15 minutes
Fasting
Fasting is not required
Included Services
- There are no numerical values. The tissue expression is read qualitatively:
- Positive (strong and pathological): Strong and widespread cytoplasmic and membranous staining in the majority of tumor cells. This is the typical pattern in synovial sarcoma.
- Negative or weak: absence of staining or weak, mottled staining. Strong, homogeneous cytoplasmic staining in a fusiform tumor is the definitive indicator.
Medical Service Information
Conditions & Notices
- Fasting is not required, as the sample is a surgical tissue sample.
- The tissue sample must be immediately preserved in 10% formalin.
- This analysis is routinely requested when synovial sarcoma or any nonspecific spindle-shaped soft tissue tumor is suspected.
- It is often requested as part of a diagnostic package for spindle cell soft tissue tumors, with markers such as TLE1, EMA, CD99, and BCOR. FISH testing for t(X;18) chromosomal translocation is strongly recommended, either concurrently or subsequently, to confirm the diagnosis.
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