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Lahalak Medical PlatformDifferentiate Care
Microsatellite Instability (MSI) Test
The key to modern immunotherapy! The MSI test detects DNA repair defects, determining how well colon and endometrial tumors will respond to personalized and effective immunotherapy treatments.
The immunohistochemical assay for microsatellite instability (MSI) or loss of mismatch repair (MMR) protein expression aims to evaluate the status of four key proteins in the MMR system (MLH1, MSH2, MSH6, and PMS2) within cancer cell nuclei. It determines whether a tumor exhibits high microsatellite instability (MSI-H), which is associated with loss of expression of one or more of these proteins, thus making it a candidate for immunotherapy.
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