Are there any preparations before the test?

You may be asked to fast or avoid certain medications before the test. It is best to consult your doctor for specific instructions.

What are the risks associated with the test?

Risks related to blood drawing include bruising or mild pain at the puncture site; these are rare and usually minor.

What do high or low results mean?

A positive result indicates the presence of Protein C resistance, which may increase the risk of blood clots. A negative result indicates no resistance.

Can the test be repeated regularly?

Yes, it may be recommended periodically to monitor individuals at risk for clotting or to evaluate treatment effectiveness.

Medical Laboratories

Blood Clotting Resistance Test

Activated Protein C Resistance (APCR) Test

An advanced test to evaluate blood clotting ability and detect resistance to activated protein C, helping prevent risks of venous thrombosis and circulatory disorders.

Trusted medical contentUpdated: 25-04-2026Views: 51LHL-127

About this service

Activated Protein C Resistance (APCRV) analysis in citrated plasma is a laboratory test used to assess the blood’s ability to clot and to determine the presence of resistance to activated protein C, a protein that plays a vital role in regulating the blood coagulation process. This analysis is an important tool for diagnosing risks associated with coagulation disorders such as deep vein thrombosis and stroke, and it is particularly used to identify individuals at higher risk of thrombosis. The results can reveal the presence of genetic mutations or other disorders that affect protein C function, helping physicians develop appropriate treatment and prevention plans. Thanks to its accuracy, this analysis contributes to improving the understanding of vascular health and providing personalized medical care.

Purpose Test

Presence of Activated Protein C Resistance: The test helps determine whether there is resistance to Protein C, a protein that plays a vital role in regulating blood clotting.
Clotting Disorders: The test can reveal clotting disorders, such as deep vein thrombosis or arterial thrombosis syndrome, which may increase the risk of these conditions.
Genetic Mutations: It may help identify known genetic mutations leading to Protein C resistance, such as the well-known mutation in the FV (Factor V Leiden) gene.
Risk Assessment: Used to evaluate individual risk for clotting problems, especially in those with a family history of clotting disorders or certain medical conditions.
Guiding Treatment: Provides important information for doctors to develop appropriate treatment plans, such as anticoagulant therapy or management of clotting risks.

Recommended groups

Individuals with a family history of clotting disorders: Those with relatives who have experienced recurrent or unexplained blood clots are at higher risk of clotting problems.
Patients with a history of deep vein thrombosis or strokes: Individuals who have suffered from these conditions, especially at a young age or without clear risk factors.
Individuals with certain medical conditions: Such as severe myasthenia or chronic inflammatory conditions, which may increase the risk of clotting disorders.
Pregnant women: Recommended for pregnant women with a history of thrombosis or other risk factors to assess potential risks during pregnancy.
Individuals on anticoagulant therapy: To evaluate treatment effectiveness and assess risks associated with ongoing anticoagulant use.
Individuals with unexplained symptoms: Such as leg pain, swelling, or sudden changes in health status, which may indicate clotting problems.

Symptoms indicative

Swelling in legs or feet: Unexplained swelling in the legs or feet may indicate a blood clot.
Leg pain: Unexplained pain or a feeling of heaviness in the legs, especially when walking or standing for long periods.
Redness or warmth in a specific area: Redness or warmth in the leg or arm, which may suggest a clot.
Family history of blood clots: Relatives with unexplained or recurrent blood clots.
Unexplained stroke: A stroke occurring at a young age or without clear risk factors, requiring assessment of clotting risk.
Symptoms during pregnancy: Such as leg pain or shortness of breath, especially if the woman has a prior history of blood clots.
Changes in health status: Unexplained general weakness or fatigue, which may indicate circulatory issues.

Normal Levels

Normal Levels: The APCR Ratio is typically expected to be greater than 2.0.
Abnormal Results: An APCR Ratio below 2.0 indicates resistance to activated Protein C.
Interpreting Results: Results should always be interpreted in consultation with a doctor, as different clinical factors can affect outcomes.
Genetic Mutations: If resistance is detected, additional testing for genetic mutations such as FV Leiden may be recommended.
Always discuss test results with your physician to understand the health implications and possible next steps.

Frequently Asked Questions

Short answers to the FAQs published with this service.

What is the Activated Protein C Resistance (APCRV) Test?

It is a test used to evaluate the blood’s ability to clot and detect resistance to activated Protein C, which may indicate clotting disorders.

Why is this test performed?

It is used to diagnose clotting disorders, such as thrombophilia, and to assess risk in individuals with a family history of blood clots.

How is the test performed?

The test requires a blood sample, usually analyzed in the lab using cultured plasma.

How long does it take to get results?

Blood Clotting Resistance Test

About this service

Purpose Test

Recommended groups

Symptoms indicative

Normal Levels

What is included?

Conditions and notices

Frequently Asked Questions

References and additional resources

Scientific references

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