Immunohistochemical assay for MUC4 (Mucin 4) aims to detect this membrane-associated mucoglycoprotein. MUC4 is a highly sensitive and specific marker for synovial sarcoma (SS), being expressed in >90% of cases regardless of histological type (monophagus, biphasic). It is also expressed in many adenocarcinomas, particularly of the pancreas and lung.