Question 1

Purpose of the Procedure

Accepted Answer

Screening for Lynch syndrome, a hereditary condition increasing cancer risk. Determining if the tumor is likely to respond to immunotherapy drugs. Assessing the functionality of the DNA mismatch repair system in tumor cells.

Question 2

Who Should Get This Test?

Accepted Answer

Patients diagnosed with colorectal cancer to guide treatment. Patients with endometrial (uterine) cancer. Individuals with a strong family history of Lynch syndrome-related cancers.

Question 3

Understanding Results

Accepted Answer

Intact Expression: Means the MMR proteins are functioning normally. Loss of Expression: Indicates a deficiency (dMMR), suggesting potential benefit from immunotherapy or need for genetic counseling.

Precision Insights for Targeted Immunotherapy - Mismatch Repair (MMR) Immunohistochemistry