E-Cadherin Test for Tumor Spread - Immunohistochemistry: E-Cadherin

Immunohistochemistry for E-Cadherin aims to detect this essential membrane protein for adherens junctions between epithelial cells. E-Cadherin is a key marker for maintaining tissue cohesion, and the loss of its expression is associated with increased cancer cell invasion and migration (epithelial-mesenchymal transition), which is crucial in classifying certain tumors like lobular breast carcinoma.