Differentiating Lung and Urinary Cancers - Immunohistochemistry (IHC) for P63

Immunohistochemical assay for p63 (a member of the p53 protein family) aims to detect this nuclear transcription factor expressed in basal cells and the underlying layers of stratified squamous epithelium, as well as in myoepithelial cells of the breast and prostate, and transitional epithelial cells of the bladder. It is used as a highly specific marker for cells of squamous, transitional, or basal origin, making it an essential tool in the diagnosis of squamous cell carcinoma in various locations.