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Medical Laboratories

Free Light Chains Assay

Serum Free Light Chains (Kappa/Lambda) Assay

Sensitive assay to monitor immune health and diagnose plasma cell disorders like multiple myeloma by accurately measuring free kappa and lambda light chain levels.

Trusted medical contentUpdated: 04-09-2026Views: 76LHL-863

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Free Light Chains Assay | Serum Free Light Chains (Kappa/Lambda) Assay

Home Service Available

Service typeLaboratory test (Blood)

Duration10-15 minutes

Fasting / preparationFasting is not required

Home serviceAvailable

Medical notice: this information is for education and service understanding. It is not a diagnosis or a recommendation for an unnecessary procedure.

About this service

The serum free light chain assay (sFLC) is a quantitative measurement of the levels of free kappa (κ) and lambda (λ) light chains in blood serum. These chains are produced as byproducts during antibody (immunoglobulin) synthesis by plasma cells. Measuring each chain individually and calculating their ratio (κ/λ) helps detect monoclonal disorders of plasma cells, where one chain is elevated while the other is decreased.

What is included?

✓A detailed analysis to measure the absolute concentration of free light chain kappa (κ) and lambda (λ) in serum, and to calculate the ratio between them.
✓Consult a hematologist or hematologist-oncologist to interpret complex results.
✓Personal support services from Halak.

Conditions and notices

Fasting is not required
Fasting is not required, but fasting for 8-12 hours is recommended for some measurement methods. Specific laboratory instructions must be followed.
The doctor should be informed of any medications the patient is taking, although their direct effect is limited. It is important to know if the patient has recently received medications containing antibodies (such as intravenous immunoglobulin, or IVIG) because these may affect the results.
No other special preparations are required.

Frequently Asked Questions

Short answers to the FAQs published with this service.

• What exactly does the Serum Free Light Chain Assay measure?

The assay provides a quantitative measurement of the levels of kappa (κ) and lambda (λ) free light chains present in the blood serum.

• Are there any fasting requirements for this blood test?

No, fasting is not required before undergoing the Serum Free Light Chain Assay.

• Can this test help evaluate conditions other than Multiple Myeloma?

Yes, it assists in the diagnosis and evaluation of Amyloidosis, which is caused by light chain deposition, as well as Solitary Plasmacytoma.

• Which patient groups are typically targeted for this assay?

The test is intended for individuals showing symptoms suggestive of Multiple Myeloma, previously diagnosed patients requiring monitoring for treatment effectiveness or relapse, and those whose protein electrophoresis results show a monoclonal protein.

• Why might this test be ordered for someone with a small M-Protein in their SPEP results?

The assay is used to assist those individuals who show an undefined or very small monoclonal protein (M-Protein) during a protein electrophoresis (SPEP) test.

• What is the biological origin of the free light chains being measured?

These chains are produced as excess byproducts during the body's synthesis of antibodies (immunoglobulins).

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Important Notice:

Content on LahaLak is provided for educational purposes only. It is not a medical diagnosis, prescription, or substitute for consulting a qualified clinician. Medical decisions should not be made from this content alone.

Content reviewed according to the LahaLak Quality Charter.Editorial Policy & Medical Standards

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Medical Laboratories

Free Light Chains Assay

Serum Free Light Chains (Kappa/Lambda) Assay

Sensitive assay to monitor immune health and diagnose plasma cell disorders like multiple myeloma by accurately measuring free kappa and lambda light chain levels.

Trusted medical contentUpdated: 04-09-2026Views: 76LHL-863

View service availability

Home Service Available

Service typeLaboratory test (Blood)

Duration10-15 minutes

Fasting / preparationFasting is not required

Home serviceAvailable

Medical notice: this information is for education and service understanding. It is not a diagnosis or a recommendation for an unnecessary procedure.

About this service

What is included?

✓A detailed analysis to measure the absolute concentration of free light chain kappa (κ) and lambda (λ) in serum, and to calculate the ratio between them.
✓Consult a hematologist or hematologist-oncologist to interpret complex results.
✓Personal support services from Halak.

Conditions and notices

Fasting is not required
Fasting is not required, but fasting for 8-12 hours is recommended for some measurement methods. Specific laboratory instructions must be followed.
The doctor should be informed of any medications the patient is taking, although their direct effect is limited. It is important to know if the patient has recently received medications containing antibodies (such as intravenous immunoglobulin, or IVIG) because these may affect the results.
No other special preparations are required.