Diagnosis of Hemophilia A (Factor VIII deficiency) and determination of its severity (mild, moderate, severe) based on the percentage of remaining activity. Distinguishing Hemophilia A from other clotting disorders, especially von Willebrand disease, when there is a family history or bleeding symptoms. Monitoring the effectiveness of replacement therapy with concentrated Factor VIII or newer treatments (e.g., Emicizumab) in known patients, and ensuring that therapeutic levels are reached. Evaluating the cause of prolonged activated partial thromboplastin time (aPTT) in routine coagulation tests.

Male children (0-12 years): Especially when signs of abnormal bleeding appear (such as large bruises, joint swelling, prolonged bleeding after circumcision) or when there is a strong family history of Hemophilia A. Adolescents and men: Who have been previously diagnosed with Hemophilia A, for routine follow-up and assessment of the adequacy of prophylactic treatment or when preparing for surgery. Female carriers (Carriers): Testing may be requested to assess their Factor VIII levels, as some carriers may have low levels and experience mild bleeding symptoms. Chronic patients: Those with Hemophilia A who need ongoing monitoring before surgeries, after bleeding events, or as part of routine care.

Family history of Hemophilia A or undiagnosed bleeding disorders. Easy bruising and deep bruises, or bleeding under the skin with minor trauma. Frequent or prolonged bleeding from small cuts, or after tooth extraction or any surgical procedure. Spontaneous bleeding within joints (knees, elbows, ankles) causing pain, swelling, and stiffness. Frequent or severe nosebleeds (epistaxis) that are hard to stop. Abnormal results in the activated partial thromboplastin time (aPTT) test.

6% - 49%: Mild Hemophilia A 1% - 5%: Moderate Hemophilia A Less than 1%: Severe Hemophilia A

Factor VIII Coagulation Test | Lahalak Platform

A specialized test to evaluate Factor VIII activity, crucial for diagnosing Hemophilia A and managing bleeding disorders effectively for your long-term health.

Scientific name: Factor VIII:C Coagulation Activity Test

A specialized test to evaluate the coagulation system that measures the functional activity of Factor VIII (Factor VIII:C) in plasma, expressed as a percentage of normal activity. Factor VIII is a crucial protein in the intrinsic pathway of coagulation, acting as a cofactor for Factor IX. Its quantitative or functional deficiency is the direct caus...

Factor VIII:C Coagulation Activity Test - Monitor Factor VIII Clotting

Service type Laboratory test (Blood)

Duration 10-15 minutes

Fasting Fasting is not required

Included Services

Factor VIII:C Coagulation Function Test
Consultation for result interpretation with a hematologist or a specialist in coagulation disorders.
Personal support services from Lahalak

Medical Service Information

Purpose Test

Diagnosis of Hemophilia A (Factor VIII deficiency) and determination of its severity (mild, moderate, severe) based on the percentage of remaining activity.
Distinguishing Hemophilia A from other clotting disorders, especially von Willebrand disease, when there is a family history or bleeding symptoms.
Monitoring the effectiveness of replacement therapy with concentrated Factor VIII or newer treatments (e.g., Emicizumab) in known patients, and ensuring that therapeutic levels are reached.
Evaluating the cause of prolonged activated partial thromboplastin time (aPTT) in routine coagulation tests.

Recommended groups

Male children (0-12 years): Especially when signs of abnormal bleeding appear (such as large bruises, joint swelling, prolonged bleeding after circumcision) or when there is a strong family history of Hemophilia A.
Adolescents and men: Who have been previously diagnosed with Hemophilia A, for routine follow-up and assessment of the adequacy of prophylactic treatment or when preparing for surgery.
Female carriers (Carriers): Testing may be requested to assess their Factor VIII levels, as some carriers may have low levels and experience mild bleeding symptoms.
Chronic patients: Those with Hemophilia A who need ongoing monitoring before surgeries, after bleeding events, or as part of routine care.

Symptoms indicative

Family history of Hemophilia A or undiagnosed bleeding disorders.
Easy bruising and deep bruises, or bleeding under the skin with minor trauma.
Frequent or prolonged bleeding from small cuts, or after tooth extraction or any surgical procedure.
Spontaneous bleeding within joints (knees, elbows, ankles) causing pain, swelling, and stiffness.
Frequent or severe nosebleeds (epistaxis) that are hard to stop.
Abnormal results in the activated partial thromboplastin time (aPTT) test.

Frequently Asked Questions (FAQs)

What is the difference between Hemophilia A and von Willebrand disease? Hemophilia A is a deficiency in Factor VIII only and is X-linked (mostly affecting males). Von Willebrand disease is a deficiency or dysfunction in von Willebrand factor, which carries and stabilizes Factor VIII and helps platelets adhere. Symptoms of von Willebrand disease are usually milder and affect both genders equally. It may present with bleeding from mucosal surfaces (nose, gums, heavy menstrual bleeding).
How is the Factor VIII activity result interpreted? The result is given as a percentage of normal activity (around 100%). Normal: 50-150% Mild Hemophilia: 6-49% (bleeding usually after major trauma or surgery). Moderate Hemophilia: 1-5% (bleeding after minor trauma, occasional spontaneous bleeding). Severe Hemophilia:
Normal: 50-150%
Mild Hemophilia: 6-49% (bleeding usually after major trauma or surgery).
Moderate Hemophilia: 1-5% (bleeding after minor trauma, occasional spontaneous bleeding).
Severe Hemophilia:

Normal Levels

6% - 49%: Mild Hemophilia A
1% - 5%: Moderate Hemophilia A
Less than 1%: Severe Hemophilia A

Conditions & Notices

It is preferable to fast for 8-12 hours before sample collection to avoid interference from lipemia in some measurement methods, although some protocols may not explicitly require this.
Inform the doctor or laboratory about all medications, especially anticoagulants (such as warfarin, heparin), as coordination with the doctor is necessary to stop them for an adequate period before the test, if possible.
The blood draw should be performed ideally and quickly to avoid activating coagulation inside the needle or tube, which may consume the factors and affect the result.
It is recommended to avoid performing the test during an acute bleeding episode or immediately after a blood/Factor VIII transfusion, as the results will not reflect the patient's baseline level.