Question 1

Purpose of Testing

Accepted Answer

Identify germline mutations in the TP53 gene. Assess the lifetime risk of developing associated cancers. Guide family members toward necessary preventive screening.

Question 2

Who Should Get Tested

Accepted Answer

Individuals diagnosed with rare cancers at an early age. People with a strong family history of Li-Fraumeni syndrome. Patients diagnosed with multiple primary tumors.

Question 3

Clinical Significance

Accepted Answer

Enables high-intensity cancer surveillance protocols. Assists clinicians in making personalized treatment decisions. Provides vital information for family planning and genetic counseling.

Understand Your Genetic Cancer Risk - TP53 Gene Sequencing for Li-Fraumeni Syndrome