Metanephrine analysis (by Liquid Chromatography-Tandem Mass Spectrometry - LC-MS/MS) is used to measure metanephrine levels in blood or urine. Metanephrine is a metabolic product of catecholamine hormones such as adrenaline and noradrenaline. This analysis is an important tool in diagnosing disorders related to the adrenal gland, such as catecholamine-secreting adrenal tumors. The liquid chromatography with tandem mass spectrometry (LC-MS/MS) technique provides high precision in measurement, helping doctors detect any abnormal increase in metanephrine levels. This test is often performed on individuals who exhibit symptoms such as sudden high blood pressure, rapid heart rate, or excessive anxiety. Positive results may indicate the presence of adrenal tumors, which requires further evaluation and treatment.