The Isotretinoin Monitoring Panel (IOCT) is a set of essential laboratory tests for patients receiving isotretinoin (IOCT) for the treatment of severe and persistent acne. This laboratory protocol aims to monitor potential side effects of the drug, including elevated liver enzymes (an indicator of liver toxicity), elevated blood lipids (cholesterol and triglycerides), and changes in blood counts. This periodic monitoring is mandatory and standard before and during treatment.