A highly advanced analytical consultation package focusing on therapy resistance mechanisms. It relies on the systematic analysis of eight immunohistochemical (IHC) markers selected to cover diverse biological pathways associated with resistance: 1) DNA repair and genomic instability, 2) apoptosis, 3) growth and compensatory signaling, 4) drug transport, 5) metabolism, 6) cancer stem cells, 7) tumor microenvironment, and 8) alternative survival signals. The results are reviewed by a team of molecular oncology and pathology experts to identify the dominant mechanism or mechanisms of resistance in the tumor under examination and to develop strategies for overcoming them.