Question 1

Purpose of the Procedure

Accepted Answer

Identify patients with hereditary Lynch syndrome. Assess the risk of developing future secondary cancers. Assist family members in initiating early preventive screenings. Guide oncologists in selecting the most effective immunotherapy.

Question 2

Who Should Get Tested

Accepted Answer

Patients diagnosed with colorectal cancer. Patients diagnosed with endometrial cancer. Individuals with a strong family history of early-onset cancers.

Question 3

Clinical Significance

Accepted Answer

Normal Result: Indicates presence of MMR proteins and low risk of Lynch syndrome. Abnormal Result: Indicates loss of protein expression, requiring further genetic testing.

Lynch Syndrome Early Screening - Immunohistochemistry (IHC) for MMR Proteins (Lynch Syndrome)