Question 1

Purpose of the Test

Accepted Answer

Accurate molecular subtyping of the tumor Predicting response to radiation or chemotherapy Screening for hereditary Lynch syndrome via MMR proteins

Question 2

Targeted Biomarkers

Accepted Answer

p53 Protein: To identify high-risk serous-like features PTEN Protein: To evaluate cell growth pathways MMR Proteins: To assess DNA mismatch repair status

Question 3

When is this test required?

Accepted Answer

Following a hysterectomy or endometrial biopsy To guide decisions regarding adjuvant therapy For patients diagnosed with endometrial adenocarcinoma

Precise Endometrial Cancer Subtyping - Immunohistochemistry (IHC) for Endometrial Carcinoma