Immunohistochemical assay for GATA3 (GATA Binding Protein 3) aims to detect this nuclear transcription factor, which plays a crucial role in the differentiation of epithelial cells in the breast, thyroid gland, and genitourinary tract. It is considered a highly sensitive and specific marker for breast cancer (especially ER+ hormone-dependent cancers) and for urothelial carcinoma of the bladder and ureter.