Calretinin Mesothelioma Diagnosis - Immunohistochemistry: Calretinin Test

Immunohistochemistry is used to detect the expression of calretinin, a calcium-binding protein found in mesothelial cells and, in some areas, nerve cells. It is a key positive diagnostic marker for both normal and malignant mesothelial cells (mesothelial tumors), and a negative marker for adenocarcinomas that resemble them, particularly in pleural and endothelial effusions.