BAP1 Mutation Tumor Test - Immunohistochemistry: BAP1 Test

Immunohistochemistry is used to detect the expression of BAP1 (BRCA1 Associated Protein 1) in cell nuclei. Loss of nuclear expression of the protein (loss of nuclear staining) usually indicates a pathogenic mutation in the BAP1 gene. It is used as a diagnostic marker and a prognostic aid in a range of tumors, including melanoma, mesothelioma, kidney cancer, and other tumors.