Leukemia Gene Mutation Test - BCR/ABL Fusion Gene Test

The BCR-ABL fusion gene test is an advanced molecular analysis (typically using polymerase chain reaction - PCR) to detect a specific chromosomal mutation called the Philadelphia chromosome. This mutation results from an abnormal fusion of the BCR gene on chromosome 22 and the ABL gene on chromosome 9, leading to the production of an oncogenic protein that causes uncontrolled proliferation of white blood cells.