Celiac Disease Diagnostic Test - Anti-Tissue Transglutaminase IgA Test

A serological test detects IgA autoantibodies directed against tissue transglutaminase (tTG). This test is considered the most sensitive and specific for diagnosing celiac disease, with an accuracy rate exceeding 95%. The titer of these antibodies in the blood rises when a person with celiac disease consumes gluten, as tTG acts as the primary antigen in the harmful immune response that occurs in the small intestine.