Autoimmune Overlap Syndrome Test - Anti-PM/Scl Antibody Test

A serological test detects autoantibodies directed against a nuclear protein complex known as PM/Scl (or PM-1). These antibodies are associated with overlap syndrome, which combines features of myositis, particularly dermatomyositis or polymyositis, with features of scleroderma, particularly limited systemic sclerosis. It occurs in approximately 8–12% of patients with myositis and about 3% of patients with scleroderma.