Immunohistochemistry for High Molecular Weight Cytokeratin (HMW CK, such as CK5, CK14, CK17) aims to detect a group of keratins typically found in the basal and parabasal layers of stratified epithelium and in myoepithelial cells. They are expressed in undifferentiated or progenitor cells and are useful in diagnosing and classifying certain tumors, particularly in the breast and prostate.