Immunohistochemical (IHC) testing for immunoglobulin G (IgG) aims to detect the presence and distribution of this type of antibody in tissue samples. It is primarily used in the evaluation of autoimmune kidney diseases (nephritis), autoimmune cutaneous diseases, and autoimmune vascular diseases. Detecting a specific pattern of IgG deposits (e.g., along the glomerular basement membrane) is a vital diagnostic tool.