Question 1

Purpose of the Screen

Accepted Answer

Early detection of open neural tube defects (ONTD). Assessing the risk of spina bifida and anencephaly. Identifying pregnancies that require follow-up detailed ultrasounds.

Question 2

Optimal Timing

Accepted Answer

Performed during the second trimester. The ideal window is between 16 and 18 weeks of gestation. Technically feasible from week 15 through week 20.

Question 3

Understanding Results

Accepted Answer

High levels may suggest neural tube defects or multiple pregnancies. Low levels may sometimes be associated with chromosomal abnormalities. This is a screening test, not a definitive diagnostic tool.

Ensure Your Baby's Safety - Maternal Serum Alpha-fetoprotein (MSAFP) Screen