Anti-Mitochondrial Antibody Test - Anti-Mitochondrial Antibody (AMA) Screening

A serological test detects autoantibodies directed against mitochondrial antigens (AMAs), particularly against pyruvate dehydrogenase 2 (PDC-E2). These antibodies are highly specific for diagnosing primary biliary cholangitis (PBC), appearing in 90–95% of cases. AMA titers are typically elevated (>1:40) in PBC and often predict more severe disease.