The Integrated Consultative Package combines advanced immunopathology and systems bioinformatics. It includes multi-layer integration of nineteen immunohistochemical (IHC) markers, which are linked—where data are available—to additional information from other biological layers, such as gene mutations (from NGS) or protein expression profiles. A multi-layered model of the tumor is constructed, identifying concurrent vulnerabilities across different pathways. This model is reviewed by a team of precision medicine scientists and systems bioinformaticians to generate transformative protocols, which may involve switching the entire treatment class or incorporating unconventional therapies.