Clozapine Serum by Liquid Chromatography–Tandem Mass Spectrometry (LC-MS/MS) is used to determine clozapine levels in blood serum. Clozapine is an effective psychiatric medication for the treatment of schizophrenia, but it carries potential risks including toxicity and serious side effects. This analysis provides high accuracy in measuring clozapine concentration, helping physicians adjust dosages and monitor patient response to therapy. This technique is considered ideal due to its ability to distinguish clozapine from its other components, contributing to improved patient care and risk reduction.