Bone and Soft Tissue Diagnosis - Immunohistochemistry (IHC): CD99

This diagnostic package, based on immunohistochemistry, includes the screening of a range of markers for the diagnosis of Ewing sarcoma (EFTs) and other small round cell sarcomas. The package primarily includes testing for CD99 (MIC2), a potent cytoplasmic membrane marker strongly expressed in Ewing sarcomas, as well as essential complementary markers: NKX2.2 (a high-specific nuclear transcription factor for EFTs), neuronal cell markers such as Synaptophysin, and lymphoma markers such as CD45 (LCA) and the T-cell marker CD3. The package aims to confirm the diagnosis of Ewing sarcomas and differentiate them from major differential diagnoses such as lymphoma, small cell carcinoma, and small cell sarcoma.