Anti-Histone Antibody Test

Serological tests detect autoantibodies directed against histone proteins, the essential proteins around which DNA wraps to form nucleosomes in the cell nucleus. These antibodies are commonly associated with drug-induced lupus erythematosus (DIL), appearing in more than 95% of cases. They may also be found in a smaller percentage of patients with primary systemic lupus erythematosus (SLE) (30–80%), but are usually accompanied by other antibodies such as anti-dsDNA.