Scleroderma Diagnostic Antibody Test - Anti-Centromere Antibody (CENP-B) Test

A serological test detects autoantibodies directed against centromere proteins, particularly CENP-B. These antibodies are positive in approximately 60–80% of patients with limited cutaneous systemic sclerosis, including CREST syndrome. This test is highly specific for this subtype of systemic sclerosis and is rarely seen in diffuse forms of the disease or other connective tissue disorders.