The anti-endometricular antibody (IgA) test is an immunological test that detects the presence of IgA antibodies directed against a connective tissue protein surrounding the smooth muscle fibers of the endomyisium. The test is typically performed using immunosorbent assay (IFA) on monkey esophageal or human intestinal tissue. The presence of these antibodies is a very strong and highly specific (>95%) marker for celiac disease, an autoimmune disorder in which the body attacks the small intestine when gluten is ingested.