A comprehensive and integrated therapeutic consultation package representing the highest level of immunohistochemical characterization. It includes in-depth and systematic analysis of fifteen immunohistochemical (IHC) markers selected to cover all clinically relevant biological aspects: diagnosis, classification, prognosis, and treatment. Advanced quantitative histological analysis techniques are combined with interpretation by a virtual international panel of experts. The package aims to produce a "Comprehensive Therapeutic Biological Profile" that serves as the ultimate reference for diagnosis, for establishing a personalized, multimodal treatment plan, and for translational research.